Title of article :
Kaurene diterpenes from Laetia thamnia inhibit the growth of human cancer cells in vitro
Author/Authors :
Henry، نويسنده , , Geneive E. and Adams، نويسنده , , Lynn S. and Rosales، نويسنده , , Jose C. and Jacobs، نويسنده , , Helen and Heber، نويسنده , , David and Seeram، نويسنده , , Navindra P.، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 2006
Abstract :
Four ent-kaurene diterpenes were isolated from the leaves of Laetia thamnia L.: ent-kaur-16-en-19-oic acid (1a), ent−3β-hydroxykaur-16-ene (2), ent-kaur-16-en-3α,19-diol (3a), and ent-17-hydroxykaur-15-en-19-oic acid (4). The methyl ester (1b) of compound 1a and the acetate diester (3b) of compound 3a were prepared, and all compounds were evaluated for cytotoxicity against human prostate (22Rv1, LNCaP), colon (HT29, HCT116, SW480, SW620), and breast (MCF-7) tumor cells at concentrations ranging from 6 to 50 μg/mL. The kaurenes showed activity in all cell lines tested, with the prostate cells demonstrating the most sensitivity as follows: 22 Rv1 cells towards 1a (IC50 5.03 μg/mL) and 1b (IC50 6.81 μg/mL), and LNCaP towards 2 (IC50 12.83 μg/mL) and 4 (IC50 17.63 μg/mL).
Keywords :
Laetia thamnia , Kaurene diterpenes , Cytotoxic
Journal title :
Cancer Letters
Journal title :
Cancer Letters