Author/Authors :
Tchatchou، نويسنده , , Sandrine and Wirtenberger، نويسنده , , Michael and Hemminki، نويسنده , , Kari and Sutter، نويسنده , , Christian and Meindl، نويسنده , , Alfons and Wappenschmidt، نويسنده , , Barbara and Kiechle، نويسنده , , Marion and Bugert، نويسنده , , Peter and Schmutzler، نويسنده , , Rita K. and Bartram، نويسنده , , Claus R. and Burwinkel، نويسنده , , Barbara، نويسنده ,
Abstract :
Aurora genes play a crucial role in tumourigenesis and are overexpressed in many kinds of cancers. We investigated whether coding variants within the Aurora genes are associated with familial breast cancer risk. While AURKA Phe31Ile (1712T>A) and AURKB Thr298Met (893G>A) showed no association, the synonymous AURKB Ser295Ser (885A>G) polymorphism resulted in an increased breast cancer risk for carriers of the homozygous 885G genotype (OR = 1.45, 95% CI = 1.05–2.0, P = 0.02). Due to the impact of aurora kinases in the loss of chromosomal integrity during carcinogenesis, this variant may also influence the therapy outcome in breast cancer.
Keywords :
case-control study , Aurora kinases , Polymorphism , breast cancer
