Title of article
Interaction between CD44 and hyaluronate induces chemoresistance in non-small cell lung cancer cell
Author/Authors
Ohashi، نويسنده , , Rina and Takahashi، نويسنده , , Fumiyuki and Cui، نويسنده , , Ri and Yoshioka، نويسنده , , Masakata and Gu، نويسنده , , Tao and Sasaki، نويسنده , , Shinichi and Tominaga، نويسنده , , Shigeru and Nishio، نويسنده , , Kazuto and Tanabe، نويسنده , , Kenneth K. and Takahashi، نويسنده , , Kazuhisa، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
10
From page
225
To page
234
Abstract
CD44s is a principle hyaluronate (HA) receptor and has been reported to play an important role in cancer cell invasion and metastasis. The aim of our study is to determine if the interaction between HA and CD44s influences in vitro chemosensitivity of non-small cell lung cancer (NSCLC). NSCLC cell line, H322 cells, transfected with the CD44s gene (H322/CD44s) cultured on HA coated plates were more resistant to cisplatin (CDDP) than that on bovine serum albumin. Multidrug resistance protein2 (MRP2) expression was induced in H322/CD44s cells cultured on HA. MRP2 inhibitor, MK571, not only suppressed MRP2 expression but also reversed CDDP resistance. These results suggest that the interaction between CD44s and HA play a pivotal role in acquired resistance to CDDP in NSCLC and MRP2 could be involved in this potential mechanism.
Keywords
Chemoresistance , CD44s , Hyaluronate , Non-small cell lung cancer , MRP2
Journal title
Cancer Letters
Serial Year
2007
Journal title
Cancer Letters
Record number
1810502
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