Title of article
Chemopreventive effects of sarcophine-diol on skin tumor development in CD-1 mice
Author/Authors
Zhang، نويسنده , , Xiaoying and Kundoor، نويسنده , , Vipra and Khalifa، نويسنده , , Sherief and Zeman، نويسنده , , David and Fahmy، نويسنده , , Hesham and Dwivedi، نويسنده , , Chandradhar and Muller، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
7
From page
53
To page
59
Abstract
The objective of this study was to determine the chemopreventive effects of sarcophine-diol (SD) on 7,12-dimethylbenz(a)anthracene initiated and 12-O-tetradecanoylphorbol-13-acetate promoted skin tumor development in mice and its possible mechanisms of action. SD pretreatment significantly (P < 0.05) decreased skin papilloma development during promotion phase. SD significantly (P < 0.05) increased caspase-3 and decreased cyclooxygenase-2 during initiation phase or promotion phase. SD significantly (P < 0.05) increased caspase-8 during promotion phase. SD resulted in a 95% reduction in 12-O-tetradecanoylphorbol-13-acetate-induced DNA synthesis. SD could be an effective chemopreventive agent for skin cancer by enhancing apoptosis and decreasing cell proliferation.
Keywords
chemoprevention , apoptosis , Cyclooxygenase-2 (COX-2) , Skin cancer , Sarcophine-diol
Journal title
Cancer Letters
Serial Year
2007
Journal title
Cancer Letters
Record number
1810542
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