Title of article
Enhanced anticancer effect of conjugated linoleic acid by conjugation with Pluronic F127 on MCF-7 breast cancer cells
Author/Authors
Guo، نويسنده , , Ding-Ding and Moon، نويسنده , , Hyun-Seuk and Arote، نويسنده , , Rohidas and Seo، نويسنده , , Ji-Hye and Quan، نويسنده , , Ji-Shan and Choi، نويسنده , , Yun-Jaie and Cho، نويسنده , , Chong-Su، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
11
From page
244
To page
254
Abstract
This study is designed to evaluate whether conjugated linoleic acid-coupled Pluronic F127 (Plu-CLA) enhances anticancer efficacy in MCF-7 breast cancer cells when compared to conjugated linoleic acid (CLA) itself. CLA was simply coupled to Pluronic F127 through ester linkage between carboxyl group of CLA and hydroxyl one of Pluronic at melting state without solvent or catalyst. Plu-CLA significantly enhanced apoptosis with increasing concentration compared with CLA itself. Moreover, it was found that p53, p21, and Bax were up-regulated, whereas Bcl-2 and procaspase 9 were down-regulated with increasing concentration of Plu-CLA. These results were attributed to the sensitization activity of Pluronic F127.
Keywords
Conjugated linoleic acid (CLA) , Pluronic F127 , apoptosis , Polymer conjugation
Journal title
Cancer Letters
Serial Year
2007
Journal title
Cancer Letters
Record number
1810670
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