Author/Authors :
Akamatsu، نويسنده , , Norihiko and Yamada، نويسنده , , Yasuaki and Hasegawa، نويسنده , , Hiroo and Makabe، نويسنده , , Koki and Asano، نويسنده , , Ryutaro and Kumagai، نويسنده , , Izumi and Murata، نويسنده , , Ken and Imaizumi، نويسنده , , Yoshitaka and Tsukasaki، نويسنده , , Kunihiro and Tsuruda، نويسنده , , Kazuto and Sugahara، نويسنده , , Kazuyuki and Atogami، نويسنده , , Sunao and Yanagihara، نويسنده , , Katsunori and Kamihira، نويسنده , , Shimeru Kamihira، نويسنده ,
Abstract :
We surveyed IL-21 receptor (IL-21R) in leukemia and lymphoma and found that follicular lymphoma cells showed exceptionally high IL-21R expression. Notably, IL-21 showed divergent effects depending on the cell origin: growth stimulation in Burkitt lymphoma cell lines and adult T cell leukemia/lymphoma cell lines but induction of apoptosis in B lymphoma cell lines with t(14;18)(q32;q21), a marker karyotype of follicular lymphoma. IL-21 activated caspase-8 and -3 and reduced mitochondrial membrane potential. More importantly, IL-21 decreased Bcl-2 expression but increased Bax expression. These results support a new therapeutic approach using the IL-21/IL-21R system in follicular lymphoma.
Keywords :
apoptosis , IL-21 , bcl-2 , follicular lymphoma
