Title of article
High IL-21 receptor expression and apoptosis induction by IL-21 in follicular lymphoma
Author/Authors
Akamatsu، نويسنده , , Norihiko and Yamada، نويسنده , , Yasuaki and Hasegawa، نويسنده , , Hiroo and Makabe، نويسنده , , Koki and Asano، نويسنده , , Ryutaro and Kumagai، نويسنده , , Izumi and Murata، نويسنده , , Ken and Imaizumi، نويسنده , , Yoshitaka and Tsukasaki، نويسنده , , Kunihiro and Tsuruda، نويسنده , , Kazuto and Sugahara، نويسنده , , Kazuyuki and Atogami، نويسنده , , Sunao and Yanagihara، نويسنده , , Katsunori and Kamihira، نويسنده , , Shimeru Kamihira، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2007
Pages
11
From page
196
To page
206
Abstract
We surveyed IL-21 receptor (IL-21R) in leukemia and lymphoma and found that follicular lymphoma cells showed exceptionally high IL-21R expression. Notably, IL-21 showed divergent effects depending on the cell origin: growth stimulation in Burkitt lymphoma cell lines and adult T cell leukemia/lymphoma cell lines but induction of apoptosis in B lymphoma cell lines with t(14;18)(q32;q21), a marker karyotype of follicular lymphoma. IL-21 activated caspase-8 and -3 and reduced mitochondrial membrane potential. More importantly, IL-21 decreased Bcl-2 expression but increased Bax expression. These results support a new therapeutic approach using the IL-21/IL-21R system in follicular lymphoma.
Keywords
apoptosis , IL-21 , bcl-2 , follicular lymphoma
Journal title
Cancer Letters
Serial Year
2007
Journal title
Cancer Letters
Record number
1810822
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