Author/Authors :
Lo، نويسنده , , Paulisally Hau Yi and Xie، نويسنده , , Dan and Chan، نويسنده , , King Chi and Xu، نويسنده , , Fang-Ping and Kuzmin، نويسنده , , Igor and Lerman، نويسنده , , Michael I. and Law، نويسنده , , Simon and Chua، نويسنده , , Daniel and Sham، نويسنده , , Jonathan and Lung، نويسنده , , Maria Li، نويسنده ,
Abstract :
Reduced expression or loss of tumor suppressor genes play a key role in many cancers. In this study, we investigated the role of RASSF1A in the pathogenesis of esophageal squamous cell carcinoma (ESCC) and nasopharyngeal carcinoma (NPC). We detected the down-regulated expression of both RASSF1A transcripts and protein in tumor tissues using RT-PCR and tissue microarray immunohistochemical staining analyses. Down-regulated expression of RASSF1A showed a significant association with WHO grade, tumor status, and lymph node metastasis, showing its possible utility as a biomarker for clinical specimens.
Keywords :
RASSF1A , Esophageal cancer , Nasopharyngeal carcinoma , Tissue microarray
