Author/Authors :
Yu، نويسنده , , Weiping and Park، نويسنده , , Sook-Kyung and Jia، نويسنده , , Li and Tiwary، نويسنده , , Richa and Scott، نويسنده , , Wenjun W. and Li، نويسنده , , Jing and Wang، نويسنده , , Pei and Simmons-Menchaca، نويسنده , , Marla and Sanders، نويسنده , , Bob G. and Kline، نويسنده , , Kimberly، نويسنده ,
Abstract :
Goal of this study was to investigate the pro-apoptotic properties of RRR-γ-tocopherol (γT) in human breast cancer cells. γT was shown to induce cancer cells but not normal cells to undergo apoptosis, sensitize cancer cells to Tumor necrosis factor-Related Apoptosis-Inducing Ligand (TRAIL)-induced apoptosis, and increase death receptor 5 (DR5) mRNA, protein and cell surface expression. Knockdown of DR5 attenuated γT-induced apoptosis. Investigations of post-receptor signaling showed: caspase-8, Bid and Bax activation, increases in mitochondria permeability, cytochrome c release and caspase-9 activation. Thus, γT is a potent pro-apoptotic agent for human breast cancer cells inducing apoptosis via activation of DR5-mediated apoptotic pathway.
Keywords :
TRAIL , apoptosis , vitamin E , Human breast cancer cells , DR5 , RRR-?-tocopherol
