Author/Authors :
Sai، نويسنده , , Kimie and Saito، نويسنده , , Yoshiro and Sakamoto، نويسنده , , Hiromi and Shirao، نويسنده , , Kuniaki and Kurose، نويسنده , , Koichi and Saeki، نويسنده , , Mayumi and Ozawa، نويسنده , , Shogo and Kaniwa، نويسنده , , Nahoko and Hirohashi، نويسنده , , Setsuo and Saijo، نويسنده , , Nagahiro and Sawada، نويسنده , , Jun-ichi and Yoshida، نويسنده , , Teruhiko، نويسنده ,
Abstract :
Recent pharmacogenetic studies on irinotecan have revealed the impact of UDP glucuronosyltransferase (UGT) 1A1∗28 on severe irinotecan toxicities. Although the clinical role of UGT1A1∗6, which is specifically detected in East Asian patients, in irinotecan toxicities is suggested, clear evidence remains limited. To examine the impact of ∗6, the association of UGT1A1 genotypes with severe irinotecan toxicities was retrospectively investigated in Japanese cancer patients. A significant ∗6-dependent increase in the incidence of grade 3 or 4 neutropenia was observed in 49 patients on irinotecan monotherapy (p = 0.012). This study further clarifies the clinical importance of ∗6 in irinotecan therapy in East Asians.
Keywords :
irinotecan , UGT1A1 , SN-38 , pharmacogenetics
