Title of article
Antibodies directed against L1-CAM synergize with Genistein in inhibiting growth and survival pathways in SKOV3ip human ovarian cancer cells
Author/Authors
Novak-Hofer، نويسنده , , Ilse and Cohrs، نويسنده , , Susan and Grünberg، نويسنده , , Jürgen and Friedli، نويسنده , , Alexandra and Schlatter، نويسنده , , Monika C. and Pfeifer، نويسنده , , Marco and Altevogt، نويسنده , , Peter and Schubiger، نويسنده , , P. August Schubiger، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
12
From page
193
To page
204
Abstract
Antibodies directed against the L1 cell adhesion protein inhibit growth of SKOV3ip human ovarian cancer cells in vitro and in vivo. Responses of SKOV3ip cells in vitro to anti-L1 mAb chCE7 and Genistein were investigated. Genistein potentiated the anti-proliferative and pro-apoptotic effects of chCE7 in SKOV3ip cells. A combination of mAb chCE7 and Genistein strongly reduced the sensitivity of p44/42 (Erk1,2) kinase, Src kinase and Akt kinase to extracellular stimulation with serum, Epidermal Growth Factor and Hepatocyte Growth Factor. The observed synergy of antibodies directed against L1 with Genistein could lead to a new therapeutic option for ovarian cancer.
Keywords
SKOV3ip cells , L1-CAM , Genistein , Anti-L1 antibody chCE7
Journal title
Cancer Letters
Serial Year
2008
Journal title
Cancer Letters
Record number
1811521
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