Author/Authors :
Yanai، نويسنده , , Kosuke and Nakamura، نويسنده , , Masafumi and Akiyoshi، نويسنده , , Takashi and Nagai، نويسنده , , Shuntaro and Wada، نويسنده , , Junji and Koga، نويسنده , , Kenichiro and Noshiro، نويسنده , , Hirokazu and Nagai، نويسنده , , Eishi and Tsuneyoshi، نويسنده , , Masazumi and Tanaka، نويسنده , , Masao and Katano، نويسنده , , Mitsuo، نويسنده ,
Abstract :
Morphogenic signals like Hedgehog (Hh) and Wnt are reported to play critical roles in the progression of gastric cancer. We aimed to assess the relationship between Hh and Wnt signaling pathways. In 58 gastric cancer specimens, Wnt pathway activation was inversely correlated with Hh pathway activation. When AGS gastric cancer cells, in which Wnt signaling was constitutively active, were used as a target cell line, Gli1 overexpression suppressed Wnt transcriptional activity, nuclear β-catenin accumulation and proliferation of AGS cells. Knock-down of β-catenin by siRNA suppressed Wnt pathway activity and proliferation of AGS cells. Our data may provide some clues for the treatment of gastric cancer associated with Wnt signaling activation.
Keywords :
Gastric cancer , Hedgehog signaling , WNT SIGNALING , ?-catenin , Gli1
