Author/Authors :
Liu، نويسنده , , Zhiming and Li، نويسنده , , Le-Qun and Peng، نويسنده , , Min-hao and Liu، نويسنده , , Tang-Wei and Qin، نويسنده , , Zhong and Guo، نويسنده , , Ya and Xiao، نويسنده , , Kai-Yin and Ye، نويسنده , , Xin-Ping and Mo، نويسنده , , Xin-Shao and Qin، نويسنده , , Xue and Li، نويسنده , , Shan and Yan، نويسنده , , Lu-Nan and Shen، نويسنده , , Han-Ming and Wang، نويسنده , , Lianwen and Wang، نويسنده , , Qiao and Wang، نويسنده , , Kai-bo and Liang، نويسنده , , Ren-xiang and Wei، نويسنده , , Zong-liang and Ong، نويسنده , , Choon Nam and Santella، نويسنده , , Regina M. and Peng، نويسنده , , Tao، نويسنده ,
Abstract :
Biomarkers of hepatitis B virus (HBV) infection, aflatoxin B1 (AFB1) exposure and oxidative stress were detected in 71 hepatocellular carcinoma (HCC) patients and 694 controls from southern China. Plasma level of AFB1-albumin-adducts (AAA) and protein carbonyl content (PCC) were significantly higher in the 71 HCC cases than in any age/gender matched HBV sero-status groups (p < 0.001). HCC patients positive for the p53-249 G-T mutation had a marginally higher level of PCC than those negative for the mutation (p = 0.077). HBV infection had a prominent influence on the association between AFB1 exposure and oxidative stress biomarkers in the controls. Our study indicates a significant contribution from HBV infection to oxidative stress in a population with AFB1 exposure which might substantially increase risk for HCC in this region.
Keywords :
HBV , Aflatoxin , hepatocellular carcinoma , oxidative stress
