Author/Authors :
Sun، نويسنده , , Wei-Hao and Zhu، نويسنده , , Feng and Chen، نويسنده , , Guo-Sheng and Su، نويسنده , , Han and Luo، نويسنده , , Cheng and Zhao، نويسنده , , Qin-Shi and Zhang، نويسنده , , Yuan and Shao، نويسنده , , Yun and Sun، نويسنده , , Jian and Zhou، نويسنده , , Su-Ming and Ding، نويسنده , , Guo-Xian and Cheng، نويسنده , , Yun-Lin، نويسنده ,
Abstract :
Gastrin and cyclooxygenase-2 (COX-2) play important roles in the carcinogenesis and progression of gastric cancer. However, it remains unknown whether the combination of cholecystokinin-2 (CCK-2) receptor antagonist plus COX-2 inhibitor exerts synergistic anti-tumor effects on human gastric cancer. Here, we demonstrated that the combination of AG-041R (a CCK-2 receptor antagonist) plus NS-398 (a selective COX-2 inhibitor) treatment had synergistic effects on proliferation inhibition, apoptosis induction, down-regulation of Bcl-2 and up-regulation of Bax expression in MKN-45 cells. These results indicate that simultaneous targeting of CCK-2 receptor and COX-2 may inhibit gastric cancer development more effectively than targeting either molecule alone.
Keywords :
apoptosis , Cholecystokinin-2 receptor , Cyclooxygenase-2 , MKN-45 cell , Proliferation
