Title of article
Free circulating mRNA in plasma from breast cancer patients and clinical outcome
Author/Authors
Garcيa، نويسنده , , Vanesa and Garcيa، نويسنده , , José M. and Peٌa، نويسنده , , Cristina and Silva، نويسنده , , Javier and Domيnguez، نويسنده , , Gemma and Lorenzo، نويسنده , , Yolanda and Diaz، نويسنده , , Raquel and Espinosa، نويسنده , , Pablo and de Sola، نويسنده , , Javier Garcيa and Cantos، نويسنده , , Blanca and Bonilla، نويسنده , , Félix، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
9
From page
312
To page
320
Abstract
We studied by real-time PCR cyclin D1 and thymidylate synthase (TS) mRNA in plasma as possible markers of clinical outcome in breast cancer. We observed poor outcome in patients with presence of cyclin D1 mRNA in good-prognosis groups, such as negative vascular invasion. Presence of both markers was associated with non-response to treatment after relapse. In patients treated with tamoxifen, a trend to significant relation between poor outcome and cyclin D1 mRNA was found. Cyclin D1 mRNA in plasma could identify patients with poor overall survival in good-prognosis groups and patients non-responsive to tamoxifen.
Keywords
PLASMA , cyclin D1 , breast cancer , ts , Prognostic , MRNA
Journal title
Cancer Letters
Serial Year
2008
Journal title
Cancer Letters
Record number
1811954
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