Author/Authors :
Zhang، نويسنده , , Zhiyong and Cao، نويسنده , , Lili and Li، نويسنده , , Jie and Liang، نويسنده , , Xiaohong and Liu، نويسنده , , Yugang and Liu، نويسنده , , Hua and Du، نويسنده , , Min-Juan and Qu، نويسنده , , Zhonghua and Cui، نويسنده , , Min and Liu، نويسنده , , Suxia and Gao، نويسنده , , Lifen and Ma، نويسنده , , Chunhong and Zhang، نويسنده , , Lining and Han، نويسنده , , Lihui and Sun، نويسنده , , Wensheng، نويسنده ,
Abstract :
Resistance to anoikis is a hallmark of human malignancies. Our results showed that hepatoma cells resisted anoikis by non-proliferation, non-apoptosis and cell cycle arrest which were termed synoikis-like. These synoikis-like cells are more resistant to extracellular stimuli and could spontaneously attach and proliferate again under suitable conditions, which indicate a reversible property of these cells. Microarray expression profile reveals the change of molecules involved in the synoikis-like hepatoma cells and our data indicated that ANGPTL4 contributed to anoikis resistance of hepatoma cells. These results demonstrated that hepatoma cells might resist anoikis through a synoikis-like survival style, which may facilitate tumor metastasis.
Keywords :
ANGPTL4 , apoptosis , Synoikis-like , Anoikis , Hepatoma
