Title of article
Inflammatory cytokine gene polymorphisms in gastric cancer cases’ and controls’ family members from Chinese areas at high cancer prevalence
Author/Authors
Feng، نويسنده , , Yunxia and Zhang، نويسنده , , Jianzhong and Dai، نويسنده , , Liping and Zhang، نويسنده , , Jianying and Wang، نويسنده , , Peng and Zang، نويسنده , , Jing and Li، نويسنده , , Yuchun and Wang، نويسنده , , Kaijuan and Zhang، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2008
Pages
10
From page
250
To page
259
Abstract
The purpose of this study was to test the associations about Helicobacter pylori infection and polymorphisms of IL-1B-31/-511 and IL-1RN VNTR polymorphism with gastric cancer in cases’ and controls’ family members from the areas of high cancer prevalence in China. IL-1B-511T and IL-1RN∗2 were associated with risks of gastric cancer. The association strength reduced with the relative degree decreasing. Such association was not found in the polymorphisms of IL-1B-31. But the haplotype analysis of IL-1B-511 and IL-1B-31 genotype could enhance the risks of gastric cancer. The positive H. pylori status could increase the risks of IL-1B to gastric cancer.
Keywords
IL-1 , polymorphisms , H. pylori , Haplotype analysis , Gastric cancer
Journal title
Cancer Letters
Serial Year
2008
Journal title
Cancer Letters
Record number
1813031
Link To Document