Author/Authors :
Matsuda، نويسنده , , Daisuke and Khoo، نويسنده , , Sok Kean and Massie، نويسنده , , Aaron and Iwamura، نويسنده , , Masatsugu and Chen، نويسنده , , Jindong and Petillo، نويسنده , , David and Wondergem، نويسنده , , Bill and Avallone، نويسنده , , Michael and Kloostra، نويسنده , , Stephanie J. and Tan، نويسنده , , Min-Han and Koeman، نويسنده , , Julie Z. Zhang، نويسنده , , Zhongfa and Kahnoski، نويسنده , , Richard J. and Baba، نويسنده , , Shiro and Teh، نويسنده , , Bin Tean، نويسنده ,
Abstract :
We report and characterize the copy number alterations (CNAs) in 35 clear cell and 12 papillary renal cell carcinomas (RCC) using Affymetrix 100K SNP arrays. Novel gain and loss regions are identified in both subtypes. In addition, statistically significant CNA are detected and associated with the pathological features: VHL mutation status, tumor grades, and sarcomatoid component in clear cell RCC and in types 1 and 2 of papillary RCC. Florescence in situ hybridization confirmed the copy number gain in the transforming growth factor, beta-induced gene (TGFBI), which is a possible oncogene for clear cell RCC.
Keywords :
Clear cell RCC , Papillary RCC , Pathological features , Copy number alterations , Beta-induced gene , transforming growth factor
