Title of article
Cathepsin B is a target of Hedgehog signaling in pancreatic cancer
Author/Authors
Hwang، نويسنده , , Jin Hyeok and Lee، نويسنده , , Sang Hyub and Lee، نويسنده , , Kwang Hyuck and Lee، نويسنده , , Keung Youp and Kim، نويسنده , , Haeryoung and Ryu، نويسنده , , Ji Kon and Yoon، نويسنده , , Yong-Bum and Kim، نويسنده , , Yong-Tae، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2009
Pages
7
From page
266
To page
272
Abstract
This study investigated the influence of cathepsin B (CATB), a downstream target of Hedgehog (Hh) signaling, in pancreatic cancer. Cyclopamine (Hh signal inhibitor) suppressed expression of Shh, as well as Hh-induced transcription factor Gli1, and induced apoptosis in Shh-positive pancreatic cancer cell line (PANC-1). Microarray analysis revealed CATB as a gene downregulated by Hh. Cyclopamine reduced CATB protein and mRNA levels. Cyclopamine or CATB inhibitor reduced PANC-1 cell invasiveness (P < 0.05). CATB expression in human pancreatic cancer tissues tended to correlate with Shh expression (P = 0.053). Conclusively, Hh targets CATB and Hh signaling through CATB might influence pancreatic cancer cell invasiveness.
Keywords
pancreatic cancer , cathepsin B , Invasion , Hedgehog gene
Journal title
Cancer Letters
Serial Year
2009
Journal title
Cancer Letters
Record number
1813400
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