Title of article
CASP8 D302H and meningioma risk: An analysis of five case-control series
Author/Authors
Bethke، نويسنده , , Lara and Sullivan، نويسنده , , Kate and Webb، نويسنده , , Emily and Murray، نويسنده , , Anne and Schoemaker، نويسنده , , Minouk and Auvinen، نويسنده , , Anssi and Kiuru، نويسنده , , Anne and Salminen، نويسنده , , Tiina and Johansen، نويسنده , , Christoffer and Christensen، نويسنده , , Helle Collatz and Muir، نويسنده , , Kenneth and McKinney، نويسنده , , Patricia and Hepworth، نويسنده , , Sarah and Dimitropoulou، نويسنده , , Polyxeni and Lophatananon، نويسنده , , Artitaya and Feychting، نويسنده , , Maria and Lِnn، نويسنده , , Stefan and Ahlbom، نويسنده , , Anders and Malmer، نويسنده , , Beatrice and Henriksson، نويسنده , , Roger and Swerdlow، نويسنده , , Anthony and Houlston، نويسنده , , Richard، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2009
Pages
4
From page
312
To page
315
Abstract
Caspase 8 (CASP8) is a key regulator of apoptosis or programmed cell death, and hence a defence against cancer. The CASP8 polymorphism D302H has recently been shown to influence the risk of breast cancer. We tested the hypothesis that the CASP8 polymorphism D302H may influence risk of meningioma through analysis of five independent series of case patients and controls (n = 631 and 637, respectively). Carrier status for 302H was not associated with a statistically significantly increased risk (OR = 1.16; 95% CI: 0.87–1.53; P = 0.31) making it unlikely that this variant contributes to the inherited risk of meningioma.
Keywords
Risk , Caspase 8 , Polymorphism , Meningioma
Journal title
Cancer Letters
Serial Year
2009
Journal title
Cancer Letters
Record number
1813417
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