Title of article
Down-regulation of stathmin is required for TGF-β inducible early gene 1 induced growth inhibition of pancreatic cancer cells
Author/Authors
Jiang، نويسنده , , Lei and Chen، نويسنده , , Yangchao and Chan، نويسنده , , Chu-yan and Wang، نويسنده , , Xin and Lin، نويسنده , , Lin and He، نويسنده , , Ming-liang and Lin، نويسنده , , Marie C.M. and Yew، نويسنده , , David T. and Sung، نويسنده , , Joseph J.Y. and Li، نويسنده , , Ji-Cheng and Kung، نويسنده , , Hsiang-fu، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2009
Pages
8
From page
101
To page
108
Abstract
Transforming growth factor-beta (TGF-β) inducible early gene 1 (TIEG1) is known to induce apoptosis in TGF-β sensitive pancreatic cancer cells, yet its effect on TGF-β resistant cancer cells remains unclear. In this study, TIEG1 was found to induce apoptosis in TGF-β resistant cancer cells and concurrently enhanced gemcitabine chemosensitivity. Down-regulation of stathmin was noted to associate with TIEG1 expression, whilst ectopic overexpression of stathmin prevented TIEG1 mediated growth inhibition of tumor cells. Small interfering RNAs targeting stathmin inhibited pancreatic cancer cell growth. These suggest that stathmin is a downstream target of TIEG1.
Keywords
TIEG1 , pancreatic cancer , stathmin , apoptosis , Chemosensitivity
Journal title
Cancer Letters
Serial Year
2009
Journal title
Cancer Letters
Record number
1813435
Link To Document