Title of article
Genetic aberrations in soft tissue leiomyosarcoma
Author/Authors
Yang، نويسنده , , Jilong and Du، نويسنده , , Xiaoling and Chen، نويسنده , , Kexin and Ylipنن، نويسنده , , Antti and Lazar، نويسنده , , Alexander J.F. and Trent، نويسنده , , Jonathan and Lev، نويسنده , , Dina and Pollock، نويسنده , , Raphael and Hao، نويسنده , , Xishan and Hunt، نويسنده , , Kelly and Zhang، نويسنده , , Wei، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2009
Pages
8
From page
1
To page
8
Abstract
Leiomyosarcoma is a malignant mesenchymal tumor composed of cells showing smooth muscle differentiation. This tumor usually occurs in middle-aged or older adults, and forms a significant percentage of retroperitoneal, vascular, extremity, and uterine sarcomas. Leiomyosarcomas are most often associated with complex karyotypes with numerous chromosomal gains and losses. Some of these cytogenetic and molecular genetic aberrations correlate with histopathologic features and clinical outcomes. Identification of genetic alterations with specific identification of oncogenes and tumor suppressor genes may lead to additional insights into the tumorigenesis of leiomyosarcoma and the opportunity to confer the benefits of targeted therapy.
Keywords
Karyotype , Leiomyosarcoma , Genetic alteration , Array CGH , Sarcoma
Journal title
Cancer Letters
Serial Year
2009
Journal title
Cancer Letters
Record number
1813467
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