Author/Authors :
Kim، نويسنده , , Eun Jung and Che، نويسنده , , Zhong Min and Park، نويسنده , , Young Jin and Hwang، نويسنده , , Young Sun and Kim، نويسنده , , Ki Yeol and Jung، نويسنده , , Da Woon and Jeon، نويسنده , , Nam Kyung and Choi، نويسنده , , Young-Wook and Lee، نويسنده , , Eun Ju and Kim، نويسنده , , Jin، نويسنده ,
Abstract :
Our study investigated the histogenesis and biological significance of spindle cell carcinoma (SpCC) by comparing with moderately-well-differentiated squamous cell carcinoma (SCC) cell lines. Snail mRNA expression was readily detectable in the SpCC cell line, while E-cadherin was undetectable. SpCC cells showed lower proliferative and invasive activities than two other SCC cell lines. Culturing under air–liquid interface conditions promoted squamous cell differentiation, whereas fibroblastic differentiation after submerged culture with collagen, suggesting that the microenvironment may be a regulating factor of spindle cell differentiation as well as Snail expression and spindle cell change may not always entail the invasive behavior.
Keywords :
Microenvironment , Invasiveness , Spindle cell transformation , spindle cell carcinoma , Epithelial mesenchymal transition
