Over-expression of the BRMS1 family member SUDS3 does not suppress metastasis of human cancer cells

BRMS1 and SUDS3 are related members of SIN3–HDAC chromatin remodeling complexes. We hypothesized that they might have overlapping functions and that SUDS3 over-expression could compensate for BRMS1 deficiency. SUDS3 expression was ubiquitous in seven breast cell lines, regardless of metastatic potential. SUDS3 over-expression in BRMS1-non-expressing metastatic cells did not suppress metastasis, motility, osteopontin secretion, or EGF receptor expression, phenotypes associated with BRMS1-mediated metastasis suppression. This study demonstrates functional differences for BRMS1 family members and highlights how the composition of SIN3–HDAC (BRMS1/SUDS3) complexes uniquely affects protein expression and biological behaviors.