Author/Authors :
Baehs، نويسنده , , Sebastian and Herbst، نويسنده , , Andreas and Thieme، نويسنده , , Susanne E. and Perschl، نويسنده , , Claudia and Behrens، نويسنده , , Andrea and Scheel، نويسنده , , Silvio and Jung، نويسنده , , Andreas and Brabletz، نويسنده , , Thomas and Gِke، نويسنده , , Burkhard and Blum، نويسنده , , Helmut and Kolligs، نويسنده , , Frank T.، نويسنده ,
Abstract :
Like Dickkopf-1 (DKK1), DKK4 is a target of β-catenin/Tcf-4 in colorectal cancer. However, as a negative regulator of Wnt signalling its function in colorectal cancer cells is not well understood. We report that DKK4 is frequently down-regulated in colorectal cancer cell lines with deregulated β-catenin/Tcf-4 and in primary colorectal cancers. Exposure of cancer cells to DKK4 strongly inhibits basal β-catenin/Tcf-4 signalling activity, cancer cell growth and cell cycle progression. Therefore, loss of this negative feed-back loop provides Wnt factor expressing cancer cells with a growth advantage. Our data demonstrate that DKK4 is an important negative regulator of colon cancer cell growth.
Keywords :
?-catenin , Colorectal Cancer , Wnt , Dickkopf , DKK4
