Title of article
High concentrations of ascorbic acid induces apoptosis of human gastric cancer cell by p38-MAP kinase-dependent up-regulation of transferrin receptor
Author/Authors
Ha، نويسنده , , Yu Mi and Park، نويسنده , , Min Kyu and Kim، نويسنده , , Hye Jung and Seo، نويسنده , , Han Geuk and Lee، نويسنده , , Jae Heun and Chang، نويسنده , , Ki Churl، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2009
Pages
7
From page
48
To page
54
Abstract
We investigated the molecular mechanism by which ascorbic acid (AA) induces apoptosis in human gastric cancer cells, AGS cells. High concentration (more than 5 mM) of AA increased cellular iron uptake by increasing transferrin receptor (TfR) expression and induced AGS cell apoptosis which was inhibited by catalase. Interestingly, p38 mitogen-activated protein kinase (MAPK) inhibitor inhibited the upregulation of TfR and increased cell survival by AA. TfR-siRNA-transfected cells reduced apoptosis by AA. H2O2 increased TfR expression in AGS cells. Taken together, we concluded that high concentration of AA, through H2O2, induces apoptosis of AGS cells by p38-MAPK-dependent upregulation of TfR.
Keywords
ascorbic acid , p38-MAPK , Transferrin receptor , Hydrogen peroxide , apoptosis
Journal title
Cancer Letters
Serial Year
2009
Journal title
Cancer Letters
Record number
1813538
Link To Document