Title of article
Naïve human umbilical cord matrix derived stem cells significantly attenuate growth of human breast cancer cells in vitro and in vivo
Author/Authors
Yuichi and Ayuzawa، نويسنده , , Rie and Doi، نويسنده , , Chiyo and Rachakatla، نويسنده , , Raja Shekar and Pyle، نويسنده , , Marla M. and Maurya، نويسنده , , Dharmendra Kumar and Troyer، نويسنده , , Deryl and Tamura، نويسنده , , Masaaki، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2009
Pages
7
From page
31
To page
37
Abstract
The effect of un-engineered (naïve) human umbilical cord matrix stem cells (hUCMSC) on the metastatic growth of MDA 231 xenografts in SCID mouse lung was examined. Three weekly IV injections of 5 × 105 hUCMSC significantly attenuated MDA 231 tumor growth as compared to the saline-injected control. IV injected hUCMSC were detected only within tumors or in close proximity to the tumors. This in vivo result was corroborated by multiple in vitro studies such as colony assay in soft agar and [3H]-thymidine uptake. These results suggest that naïve hUCMSC may be a useful tool for cancer cytotherapy.
Keywords
Human umbilical cord matrix stem cells , breast cancer , MDA 231 cells , xenografts , Colony assay
Journal title
Cancer Letters
Serial Year
2009
Journal title
Cancer Letters
Record number
1813884
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