Author/Authors :
Au، نويسنده , , Christy W.H. and Siu، نويسنده , , Michelle K.Y. and Liao، نويسنده , , Xiaoyun and Wong، نويسنده , , Esther S.Y. and Ngan، نويسنده , , Hextan Y.S. and Tam، نويسنده , , Kar Fai and Chan، نويسنده , , Dominic C.W. and Chan، نويسنده , , Queeny K.Y. and Cheung، نويسنده , , Annie N.Y. Cheung، نويسنده ,
Abstract :
In this report, we demonstrated that overexpression of tropomyosin-related kinase B (TrkB) was associated with shorter survival in ovarian cancer patients. Brain-derived neurotrophic factor (BDNF), the TrkB ligand, induced activation (phosphorylation) of TrkB in a dose dependent manner. Besides demonstrating the effect of BDNF/TrkB pathway in enhancing cancer cell migration and invasion but inhibiting apoptosis, we also report for the first time that exogenous hepatocyte growth factor induced TrkB expression at both mRNA and protein levels as well as phosphorylation. Our findings suggest that BDNF/TrkB pathway is important in ovarian carcinogenesis and TrkB may be a potential therapeutic target for ovarian cancer.
Keywords :
Invasion , apoptosis , TrkB , Ovarian cancer , Cell migration
