APPLICATION OF SODIUM C APRYLATE AS A STABILIZER DURING PASTEURIZATION OF INFUSIBLE PLATELET MEMBRANE AND EVALUATION OF ITS EFFECTIVENESS BY TURBIDITY ASSAY

For many years, sodium caprylate has been used as a suitable stabilizer to retain biological activity of pharmaceutical proteins such as human albumin solutions during pasteurization. A simple method of turbidity assay was applied for evaluation of sodium caprylate as a stabilizer to protect biological activity of infusible platelet membrane product during pasteurization at 60°C for 20 h. Concentration of sodium caprylate of samples were 0.4, 0.2, 0.1 and 0.05 M. After pasteurization, turbidity of samples was measured with spectrophotometer at optical density of 450 nm. The results were found 0.662, 1.890, 2.300, 2.365 respectively and it was concluded that sodium caprylate concentration of 0.4 M is suitable for pasteurization of infusible platelet membrane product and also turbidity assay is simple and efficient method for evaluation of this process.