Author/Authors :
BMV، Srikanth Babu نويسنده Institute of Genetics and Hospital for Genetic Disease, Osmania University, Begumpet, Hyderabad 500016, India , , Reddy B، Pulla نويسنده Institute of Genetics and Hospital for Genetic Disease, Osmania University, Begumpet, Hyderabad 500016, India , , Priya، V Hari Sai نويسنده Bhagawan Mahaveer Hospital and research center, AC Guards, Hyderabad-4 , , Munshi، Anjana نويسنده Institute of Genetics and Hospital for Genetic Disease, Osmania University, Begumpet, Hyderabad 500016, India , , Rani H، Surekha نويسنده Institute of Genetics and Hospital for Genetic Disease, Osmania University, Begumpet, Hyderabad 500016, India , , Rao V، Dayasagar نويسنده Department of Cardiology,Durga Bai Deshmukh Hospital & Research Centre, Vidyanagar,Hyderabad 500007,India , , A، Jyothy نويسنده Institute of Genetics and Hospital for Genetic Disease, Osmania University, Begumpet, Hyderabad 500016, India ,
Abstract :
Inflammation plays an important role in the pathogenesis of acute coronary syndrome (ACS). Recent studies have shown that interleukin (IL)-10, an anti inflammatory cytokine with pleiotropic properties involves in the progression of the disease, but the relationship between the genetic variants of IL-10 has not been extensively studied in the ACS patients and their first degree relatives (FDRs). The present case-control study A total of 1407 subjects including ACS patients (651) their FDRs (324) along with age and sex matched healthy controls (432) were recruited. Serum IL-10 concentrations and IL-10 gene polymorphisms were evaluated to analyse their association with susceptibility to ACS. Serum IL-10 concentrations were significantly elevated in ACS patients and FDRs (p < 0.001) in comparison with controls. IL-10 -1082 AA and -592 CC genotypes were significantly associated with the disease (p < 0.001& p=0.0021). FDRs also had shown an increase in frequency of these genotypes when compared to controls (p < 0.001). Patients having A-C (1082-592) haplotype was significantly associated with the disease (p=0.034). These results suggest that IL-10 concentrations and its polymorphisms could be involved in the risk of developing ACS in the ACS patients and their FDRs. IL-10 may be a valuable risk factor for prediction in early onset of ACS thus it can be considered as an alternative for other inflammatory markers.
