Enhancement of metastasis of prostate adenocarcinoma cells by immune-suppressive cyclosporine A

The rate and extent of metastasis by prostate adenocarcinoma-III cells was enhanced in Lobund-Wistar rats by administration of immune-suppressive cyclosporine A. PA-III cells spread from the subcutaneous PA-III-derived tumor, through ipsilateral lymph nodes, to the lungs in which they developed secondary tumors. Swollen lymph nodes, compacted with PA-III cells, indicate that the ‘normal’ host-engendered level of intravascular non-specific restraints to metastasis were abrogated by CSA.