Author/Authors :
Kapadia، نويسنده , , Govind J. and Balasubramanian، نويسنده , , Venkataraman and Tokuda، نويسنده , , Harukuni and Konoshima، نويسنده , , Takao and Takasaki، نويسنده , , Midori and Koyama، نويسنده , , Junko and Tagahaya، نويسنده , , Kiyoshi and Nishino، نويسنده , , Hoyoku، نويسنده ,
Abstract :
In continuation of our studies of natural and synthetic products as cancer chemopreventive agents, we have examined a number of naphthoquinone derivatives including monomeric, dimeric and tetrameric naphthaquinones occurring in the Diospyros and other selected plant genera. Several synthetic naphthoquinones were also evaluated. Initially these compounds were tested for in vitro anti-tumor promoting effect on Epstein-Barr virus early antigen activation produced by the tumor promoter 12-O-tetradecanoylphorbol-13-acetate (TPA) and thereafter in in vivo on two-stage mouse skin carcinogenesis. Our studies show some of these compounds have potent anti-tumor promoting activity.
