Author/Authors :
Houterman، نويسنده , , Saskia and van Faassen، نويسنده , , Arendina and Ocké، نويسنده , , Marga C. and Habets، نويسنده , , Lucien H.M. and van Dieijen-Visser، نويسنده , , Marja P. and Bueno-de-Mesquita، نويسنده , , Bas H. and Janknegt، نويسنده , , Ruud A.، نويسنده ,
Abstract :
Dietary fibers might lower the risk of colorectal cancer, maybe because of their bulking effect. We tested the protection afforded by an inert bulk against carcinogenesis. Thirty rats received an azoxymethane injection and were allocated to a control diet, or to a diet supplemented with 10% carborundum. After 100 days the colons were scored for aberrant crypt foci. Compared to controls, the fecal weight was doubled in carborundum-fed rats (P < 0.001), but the aberrant crypt foci multiplicity was not changed (P = 0.92). The results do not support the hypothesis that intestinal dilution by an inert bulk can protect against colon cancer.
Keywords :
animal protein , Colorectal Cancer , Meat , sulfate , Biomarker
