Author/Authors :
Shirzad، Maryam نويسنده Department of Horticulture, Rasht Branch, Islamic Azad University, Rasht, Iran. , , Yousofi، Mahboubeh نويسنده Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran Yousofi, Mahboubeh , Zamanzad، Behnam نويسنده Medical Plant Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran Zamanzad, Behnam , Sedaghat، Akram نويسنده Cellular and Molecular Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran Sedaghat, Akram , Hosseini، Masih نويسنده Medical Plant Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran Hosseini, Masih , Shahinfard، Najmeh نويسنده Medical Plants Research Center, Shahrekord University of Medical Sciences, Shahrekord , , Shirzad، Hedayatollah نويسنده Department of Immonology, Medical Plants Research Center, Shahr-e-Kord University of Medical Sciences, Shahr-e-Kord, Iran Shirzad, Hedayatollah
Abstract :
Introduction: Following injury, inflammatory response occurs and the cells below the dermis begin to increase collagen production, then, the epithelial tissue is regenerated. Royal jelly (RJ) has anti-inflammatory activity hence, the aim of this study was to examine the effect of RJ on the induction of sterile skin incision in Balb/C mice.
Methods: In an experimental study 60 female Balb/C mice (8 weeks old) were anaesthetized with ether and a longitudinal para vertebral full thickness incision of 10 mm long was made. The animals were divided into six equal groups. Group 1 was considered as negative control. Group 2 (positive control) was treated topically with Nitrofurazon ointment, group 3 with RJ (200 mg/kg) every day, group 4 with RJ (200 mg/kg) every two days, group 5 with RJ (300 mg/kg) every day and group 6 with RJ (300 mg/kg) every two days. The wound length was measured with vernier capilar every two days up to full healing occurred and compared in different groups.
Results: There was significant difference between groups 1 or 2 and other groups (p < 0.05). RJ promoted wound healing activity significantly in group 3, 5 compared to negative and positive control groups. There was no significant difference between the uses of 200 mg/kg and 300 mg/kg RJ (p > 0.05).
Conclusion: The results of this study indicate that daily application of RJ possesses betters wound healing effects than Nitrofurazon and every two days usage of RJ.
