Author/Authors :
Kawaura، نويسنده , , Akihiko and Tanida، نويسنده , , Noritoshi and Nishikawa، نويسنده , , Masashi and Yamamoto، نويسنده , , Issei and Sawada، نويسنده , , Kenji and Tsujiai، نويسنده , , Tsuneo and Kang، نويسنده , , Kyong Boo and Izumi، نويسنده , , Keisuke، نويسنده ,
Abstract :
The effect of 1α-hydroxyvitamin D3 (1α(OH)D3) on gastrointestinal carcinogenesis induced by N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) was investigated in male Wistar rats. After oral treatment with 0.01% MNNG for 24 weeks, rats were given 0.04 μg of 1α(OH)D3 or its vehicle by gastric intubation three times a week for 24 weeks. The incidence of gastrointestinal tumors was 16/30 (53%) in rats treated with MNNG alone, 16/30 (53%) in those treated with MNNG plus vehicle and 8/30 (27%, P<0.05) in those treated with MNNG plus 1α(OH)D3. The number of tumors per rat in the group treated with MNNG plus 1α(OH)D3 was half those in the control groups (P<0.05). Results indicated that a non-hypercalcemic dose of 1α(OH)D3 had an inhibitory effect on MNNG-induced duodeno-intestinal carcinogenesis.
Keywords :
1?-Hydroxyvitamin D3 , Rat , Stomach carcinogenesis , N-methyl-N?-nitro-N-nitrosoguanidine
