Author/Authors :
Okamoto، نويسنده , , Kazuma and Yamaguchi، نويسنده , , Toshiharu and Otsuji، نويسنده , , Eigo and Yamaoka، نويسنده , , Nobuki and Yata، نويسنده , , Yoshihiro and Tsuruta، نويسنده , , Hiroshi and Kitamura، نويسنده , , Kazuya and Takahashi، نويسنده , , Toshio، نويسنده ,
Abstract :
The murine monoclonal antibody A7 (MAb A7) is reactive against most human gastric cancer cell lines. Using a nude mouse peritoneal dissemination model of human gastric cancer, we investigated targeted chemotherapy using a conjugate of neocarzinostatin (NCS) with MAb A7 (A7-NCS). After demonstrating cytotoxicity of the complex against the human gastric cancer cell line MKN45 in vitro, we intraperitoneally injected A7-NCS, NCS or saline into nude mice bearing peritoneally disseminated human gastric cancer. A7-NCS inhibited peritoneal dissemination significantly more effectively than NCS. MAb A7 may prove to be an effective carrier for antineoplastic drugs in patients with peritoneal dissemination of gastric cancer.
Keywords :
Human gastric cancer , Peritoneal dissemination , Targeting chemotherapy , monoclonal antibody , Conjugate
