Author/Authors :
Yumita، نويسنده , , Nagahiko and Umemura، نويسنده , , Shin-ichiro and Kaneuchi، نويسنده , , Masahiro and Okano، نويسنده , , Yukihiro and Magario، نويسنده , , Naoki and Ishizaki، نويسنده , , Midori and Shimizu، نويسنده , , Keiko and Sano، نويسنده , , Yasuko and Umemura، نويسنده , , Koshiro and Nishigaki، نويسنده , , Ryuichiro، نويسنده ,
Abstract :
The ultrasonically-induced in vitro cell damaging effect of fluorine-containing anthracycline derivative (FAD104) was investigated. Sarcoma 180 cells suspended in air-saturated PBS were exposed to ultrasound for up to 60 s in the presence and absence of FAD104. The rate of inducing cell damage with ultrasound was doubled with 80 μM FAD104, while no cell damage was observed with FAD104 alone. This enhancement was significantly inhibited by histidine, which may suggest a sonochemical mechanism.
Keywords :
Ultrasound , Anthracycline derivative , Sonochemical mechanism , Cell damage , Sarcoma 180
