Author/Authors :
Ito، نويسنده , , Toshihisa and Fujieda، نويسنده , , Shigeharu and Tsuzuki، نويسنده , , Hideaki and Sunaga، نويسنده , , Hiroshi and Fan، نويسنده , , Guo-kang and Sugimoto، نويسنده , , Chizuru and Fukuda، نويسنده , , Masaru and Saito، نويسنده , , Hitoshi، نويسنده ,
Abstract :
We investigated the expression of apoptosis-related factors, p53, Bax, Bcl-2, and spontaneous apoptosis in 57 cases of oral and oropharyngeal squamous cell carcinoma (SCC) by immunochemical staining and ApopTag kit. Positive expression of Bax was inversely associated with advanced tumor stage (P=0.0225), lymph node metastasis (P=0.0225), clinical stage (P=0.0083) and poor prognosis (P=0.0478). Positive expression of p53 was related to poor prognosis (P=0.0445) and was associated with negative expression of Bax (P=0.0439). The apoptosis index did not correlate with clinical outcome. These results suggest that abnormality of Bax expression plays an important role in tumor progression in oral and oropharyngeal SCC.
Keywords :
apoptosis , Oral and oropharyngeal cancer , p53 , bcl-2 , BAX
