EFFECT OF CAREYA ARBOREA EXTRACTS ON WOUND HEALING ACTIVITY IN RATS

Careya arborea Roxb (Lecythidaceae) is known as Kumbhi in Ayurveda and is an important medicinal plant. It has been used in Ayurveda in treatment of tumours, cough, bronchitis, haemorrhoids, intestinal worms, dysentery, ulcers and eruptive fevers. The present study was carried out to determine the effect of Careya arborea extract on wound healing activity in rats. The effect was studied using different models of hound healing activity such as excision wound model, incision wound model, burn wound model and dead space wound model. The extract was applied topically at two different doses of extract Careya arborea 5% and Careya arborea 10%. Both doses of extract increased healing of wound in excision wound model. In incision wound model, breaking strength is high in both doses of extract when compare to control. Where as in case of wound contraction model, Careya arborea extract showed high wound contraction with less epithelization period and in case of dead space wound model, both doses showed significant wound healing activity. Both the doses of Careya arborea extract showed wound healing activity in all the models and the high dose of the extract was more effective compared to low dose. There for it is concluded that the Careya arborea extract increases healing of wound and posses wound healing activity in rats.