Title of article
Progression-linked overexpression of c-Met in prostatic intraepithelial neoplasia and latent as well as clinical prostate cancers
Author/Authors
Watanabe، نويسنده , , Masatoshi and Fukutome، نويسنده , , Kazuo and Kato، نويسنده , , Hiroya and Murata، نويسنده , , Mariko and Kawamura، نويسنده , , Jyuichi and Shiraishi، نويسنده , , Taizo and Yatani، نويسنده , , Ryuichi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
173
To page
178
Abstract
The c-met proto-oncogene encoding the receptor for the hepatocyte growth factor is expressed in several cancers. In the present study, c-met protein (c-Met) was detected in eight of 22 (36%) cases of prostatic intraepithelial neoplasia (PIN), five of 15 (33%) latent and 17 of 21 (81%) clinical prostate cancers, including seven metastatic lesions, using an immunohistochemical method. All seven (100%) metastatic lesions investigated demonstrated strong staining, and a correlation between c-Met expression and histology was observed. These results suggest a significant relationship between c-Met expression and progression of prostate neoplasms, including latent cancers.
Keywords
Prostatic intraepithelial neoplasia , c-Met , Latent prostate cancer
Journal title
Cancer Letters
Serial Year
1999
Journal title
Cancer Letters
Record number
1816942
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