Author/Authors :
Dagmar Bancher-Todesca، نويسنده , , Dagmar and Rosen، نويسنده , , Alexander and Graf، نويسنده , , Anton and Wasicky، نويسنده , , Richard and Hohlagschwandtner، نويسنده , , Maria and Rebhandl، نويسنده , , Winfried and Heinze، نويسنده , , Georg and Breitenecker، نويسنده , , Gerhard and Gitsch، نويسنده , , Gerald and Obermair، نويسنده , , Andreas، نويسنده ,
Abstract :
Tumor angiogenesis has been found to be prognostically significant in many types of malignant tumors. We assessed tumor vascularity in 43 cases of histologically proven primary fallopian tube cancer, FIGO stage I–IV, using the highly specific endothelial cell marker CD34. Microvessel count was determined by counting CD34-positive cells at 200× magnification. The 5-year disease-free survival probability was 43.8% (±11.5%) in 24 patients whose tumors had a microvessel count ≤19 microvessels/field and 19.7% (±9.5%) in the >19 microvessels/field group (P=0.046). Stage and microvessel count were statistically significant for disease-free survival in univariate analysis. Therefore, a larger sample size would be required to detect an independent and statistically significant prognostic effect of microvessel density in primary fallopian tube cancer in multivariate analysis.
Keywords :
Primary fallopian tube cancer , Prognostic factors , Angiogenesis , CD34 , Microvessel count
