Author/Authors :
Yanagawa، نويسنده , , Toru and Ishikawa، نويسنده , , Tomoyoshi and Ishii، نويسنده , , Tetsuro and Tabuchi، نويسنده , , Katsuhiko and Iwasa، نويسنده , , Satoshi and Bannai، نويسنده , , Shiro and Omura، نويسنده , , Ken and Suzuki، نويسنده , , Haruhiko and Yoshida، نويسنده , , Hiroshi، نويسنده ,
Abstract :
Peroxiredoxin I (Prx I) is newly discovered oxidative stress inducible protein, having a thioredoxin peroxidase activity. The Prx I expression level in 107 samples out of 60 thyroid lesions, including normal thyroid, tumors and thyroiditis including Graves’ disease were examined using immunoblotting. Prx I expression levels in follicular neoplasm (P=0.00005) and thyroiditis group (P=0.0037) were significantly higher than that of the control group, while papillary carcinoma group did not show statistical significance. Immunohistochemistry indicated that Prx I was in epithelial cells of thyroid follicles. These results suggest that Prx I is expected to be a candidate for novel tumor markers to discriminate tissue types of tumors.
Keywords :
thioredoxin peroxidase , Peroxiredoxin , Proliferating associated gene , oxidative stress , MSP23
