Title of article
Cancer chemopreventive activity of majonoside-R2 from Vietnamese ginseng, Panax vietnamensis
Author/Authors
Konoshima، نويسنده , , Takao and Takasaki، نويسنده , , Midori and Ichiishi، نويسنده , , Eiichiro and Murakami، نويسنده , , Teruo and Tokuda، نويسنده , , Harukuni and Nishino، نويسنده , , Hoyoku and Duc، نويسنده , , Nguyen Minh and Kasai، نويسنده , , Ryoji and Yamasaki، نويسنده , , Kazuo، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
6
From page
11
To page
16
Abstract
In the course of our continuing search for novel cancer chemopreventive agents from natural sources, several kinds of Panax plants were screened. Consequently, the ocotillol-type saponin, majonoside-R2 (MR2), was obtained from the rhizome and root of Panax vietnamensis (Vietnamese ginseng) as an active constituent. MR2 exhibited potent anti-tumor-promoting activity on two-stage carcinogenesis test of mouse hepatic tumor using N-nitrosodiethylamine (DEN) as an initiator and phenobarbital (PB) as a promoter. Further, MR2 exhibited the remarkable inhibitory effect on two-stage carcinogenesis test of mouse skin induced by nitric oxide (NO) donor/12-O-tetradecanoylphorbol-13-acetate (TPA) or peroxynitrite/TPA.
Keywords
Hepatic tumor inhibitor , Peroxinitrite , Majonoside-R2 , Cancer chemopreventive activity , Panax vietnamensis , Nor1
Journal title
Cancer Letters
Serial Year
1999
Journal title
Cancer Letters
Record number
1817004
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