Title of article
A new member of the GTPase superfamily that is upregulated in highly metastatic cells
Author/Authors
Nakaji، نويسنده , , Tamon and Kataoka، نويسنده , , Tatsuki R and Watabe، نويسنده , , Kenji and Nishiyama، نويسنده , , Kazutaka and Nojima، نويسنده , , Hiroshi and Shimada، نويسنده , , Yutaka S. Sato، نويسنده , , Fumiaki and Matsushima، نويسنده , , Hiroyuki and Endo، نويسنده , , Yuichi and Kuroda، نويسنده , , Yoshikazu and Kitamura، نويسنده , , Yukihiko and Ito، نويسنده , , Akihiko and Maeda، نويسنده , , Sakan، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1999
Pages
9
From page
139
To page
147
Abstract
Two sublines of B16 melanoma cells, F10 and BL6, are metastatic after intravenous injection, but only BL6 cells are metastatic after subcutaneous injection. We found a new member of the GTPase superfamily, namely TIB929, which displayed an induction of expression in BL6 cells. It conserved three consensus sequences for GTP-binding site motifs and showed a significant homology to the yeast Gtr2 gene throughout the coding sequence. TIB929 was expressed ubiquitously in human tumor cells, with a marked expression in highly metastatic cells. TIB929 was mapped on mouse chromosome 4D, syntenic to human chromosome 1p. The results suggested an involvement of TIB929 in malignant progression.
Keywords
B16 melanoma , GTP-binding protein , metastasis , Subtraction
Journal title
Cancer Letters
Serial Year
1999
Journal title
Cancer Letters
Record number
1817039
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