Author/Authors :
Nakaji، نويسنده , , Tamon and Kataoka، نويسنده , , Tatsuki R and Watabe، نويسنده , , Kenji and Nishiyama، نويسنده , , Kazutaka and Nojima، نويسنده , , Hiroshi and Shimada، نويسنده , ,
Yutaka S. Sato، نويسنده , , Fumiaki and Matsushima، نويسنده , , Hiroyuki and Endo، نويسنده , , Yuichi and Kuroda، نويسنده , , Yoshikazu and Kitamura، نويسنده , , Yukihiko and Ito، نويسنده , , Akihiko and Maeda، نويسنده , , Sakan، نويسنده ,
Abstract :
Two sublines of B16 melanoma cells, F10 and BL6, are metastatic after intravenous injection, but only BL6 cells are metastatic after subcutaneous injection. We found a new member of the GTPase superfamily, namely TIB929, which displayed an induction of expression in BL6 cells. It conserved three consensus sequences for GTP-binding site motifs and showed a significant homology to the yeast Gtr2 gene throughout the coding sequence. TIB929 was expressed ubiquitously in human tumor cells, with a marked expression in highly metastatic cells. TIB929 was mapped on mouse chromosome 4D, syntenic to human chromosome 1p. The results suggested an involvement of TIB929 in malignant progression.
Keywords :
B16 melanoma , GTP-binding protein , metastasis , Subtraction
