Author/Authors :
Yamada، نويسنده , , Yasuaki and Sugahara، نويسنده , , Kazuyuki and Tsuruda، نويسنده , , Kazuto and Nohda، نويسنده , , Kazuo and Hata، نويسنده , , Tomoko and Maeda، نويسنده , , Takahiro and Honda، نويسنده , , Miyuki and Tawara، نويسنده , , Masayuki and Hayashibara، نويسنده , , Toshihisa and Joh، نويسنده , , Tatsuroh and Tomonaga، نويسنده , , Masao and Miyazaki، نويسنده , , Yoshitsugu and Kamihira، نويسنده , , Shimeru Kamihira، نويسنده ,
Abstract :
A preventive role for human T-cell leukemia virus type-I (HTLV-I) and Fas-associated phosphatase-1 (FAP-1) in Fas-mediated apoptosis has been reported in HTLV-I-infected cells. In the present study, we examined whether these molecules increased during the acquisition of Fas-resistance in adult T-cell leukemia (ATL) cell lines. SO4, ST1 and KK1 are Fas-sensitive ATL cell lines, and produce small amounts of HTLV-I in vitro. Although their subclones RSO4 and RST1 are completely Fas-resistant, they produced an equivalent amount of HTLV-I to SO4 and ST1. Moreover, FAP-1 mRNA was not detected in these cell lines irrespective of Fas sensitivity. Thus, Fas resistance in ATL cells was not directly associated with the increased production of HTLV-I or FAP-1.
Keywords :
Human T-cell leukemia virus type-I , apoptosis , Adult T-cell leukemia , Fas , Fas-associated phosphatase-1
