Author/Authors :
Matsumoto، نويسنده , , Masataka and Natsugoe، نويسنده , , Shoji and Nakashima، نويسنده , , Saburo and Sakamoto، نويسنده , , Fuminori and Okumura، نويسنده , , Hiroshi and Sakita، نويسنده , , Hironori and Baba، نويسنده , , Masamichi and Takao، نويسنده , , Sonshin and Aikou، نويسنده , , Takashi، نويسنده ,
Abstract :
The lymph nodes of 59 patients with pN0 esophageal squamous cell carcinomas were examined immunohistochemically using cytokeratin (CK) antibody. Primary tumors were immunostained with cyclin D1 (CD1) and E-cadherin (E-cad) antibody. Lymph node micrometastasis (MM) was found in 39 (55.5%) patients. Tumor recurrence was found in 17 patients and all but one of them had MM. The 5-year survival rate was significantly poorer in patients with MM than in those without MM. Almost all patients with positive CD1 and negative E-cad expression had MM. The examination of CD1 and E-cad expression in primary tumors may be useful for predicting MM.
Keywords :
Lymph node micrometastasis , Cytokeratin , immunohistochemistry , Postoperative recurrence , Esophageal squamous cell carcinoma
