Title of article
Comparative mutagenicities of bleomycin and ferric-nitrilotriacetate in lacZ mice
Author/Authors
Kosinska، نويسنده , , Wieslawa and Pelle، نويسنده , , Edward and von Pressentin، نويسنده , , Marcia d.M. and Chen، نويسنده , , Michael and Guttenplan، نويسنده , , Joseph B.، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2002
Pages
6
From page
41
To page
46
Abstract
Bleomycin and ferric nitrilotriacetate (Fe-NTA) give rise to reactive oxygen species (ROS). Bleomycin was mutagenic in lacZ mouse kidney, liver and lung, but Fe-NTA was non-mutagenic in kidney and lung and marginally mutagenic in liver. Fe-NTA-treatment led to an increase in 8-hydroxydeoxyguanosine levels in kidney and liver, while the corresponding levels in bleomycin-treated mice were if anything, lower than those for bleomycin. It appears that factors other than simply the ability to generate ROS, play a role in mutagenesis by these compounds.
Keywords
Mutagenesis , lacZ , ferric nitrilotriacetate , Reactive oxygen species , bleomycin
Journal title
Cancer Letters
Serial Year
2002
Journal title
Cancer Letters
Record number
1817143
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