Author/Authors :
Bonassi، نويسنده , , Stefano and Abbondandolo، نويسنده , , Angelo and Camurri، نويسنده , , Lamberto and Dal Prل، نويسنده , , Leda and De Ferrari، نويسنده , , Marcella and Degrassi، نويسنده , , Francesca and Forni، نويسنده , , Alessandra and Lamberti، نويسنده , , Laura and Lando، نويسنده , , Cecilia and Padovani، نويسنده , , Paola and Sbrana، نويسنده , , Isabella and Vecchio، نويسنده , , Daniela a، نويسنده ,
Abstract :
To investigate the existence of an association between the frequency of chromosome aberrations (CA) in non-target tissues and cancer risk, a historical cohort study was carried out in a group of 1455 subjects screened for CA over the last 20 years in Italy. Statistically significant increases in standardized mortality ratio (SMR) for all cancers were found in subjects with medium and high levels of CA in peripheral blood lymphocytes (SMR = 178.5 and SMR = 182.0, respectively) and in subjects with high levels of CA for respiratory tract cancers (SMR = 250.8) and lymphatic and hematopoietic tissue neoplasms (SMR = 548.8). Significant trends in the SMRs were observed for these latter causes of death.
