Author/Authors :
Emilia، نويسنده , , Giovanni and Marasca، نويسنده , , Edson Roberto and Longo، نويسنده , , Giuseppe and Ferrari، نويسنده , , Maria Grazia and Notohamiprodjo، نويسنده , , Mathilda and Temperani، نويسنده , , Paola and Sacchi، نويسنده , , Stefano and Torelli، نويسنده , , Giuseppe، نويسنده ,
Abstract :
A 39-year-old woman was diagnosed with acute promyelocytic leukemia (APL) with disseminated intravascular coagulation syndrome. The hematologic examination showed a morphologic, cytochemical, and immunophenotypic picture typical of an APL, with a marked leukocytosis and a mixed population of hypergranular and microgranular promyelocytes. The cytogenetic analysis showed a 46,XX,t(9;22) karyotype, without any alterations of chromosomes 15 and 17. The t(15;17) translocation was not evident in FISH experiments, while a molecular analysis revealed the presence of a PML-RARα chimera.
