Title of article
Biological effects of TrkA and TrkB receptor signaling in neuroblastoma
Author/Authors
Schramm، نويسنده , , Alexander and Schulte، نويسنده , , Johannes H. and Astrahantseff، نويسنده , , Kathy and Apostolov، نويسنده , , Ognjan and Limpt، نويسنده , , Vera van and Sieverts، نويسنده , , Hauke and Kuhfittig-Kulle، نويسنده , , Steffi and Pfeiffer، نويسنده , , Petra and Versteeg، نويسنده , , Rogier and Eggert، نويسنده , , Angelika، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 2005
Pages
11
From page
143
To page
153
Abstract
The Trk family consists of three receptor tyrosine kinases, each of which can be activated by one or more of four neurotrophins—NGF, BDNF, NT3 and NT4. Neurotrophins mediate their multiple effects through a number of distinct intracellular signaling cascades regulating such diverse biological responses as cell survival, proliferation and differentiation in normal and neoplastic neuronal cells. Expression of Trk receptors also plays an important role in the biology and clinical behavior of neuroblastomas. High expression of TrkA is present in neuroblastomas with favorable biological features and highly correlated with patient survival, whereas TrkB is mainly expressed on unfavorable, aggressive neuroblastomas. This short review discusses recent data on the biological roles of TrkA and TrkB signaling in neuroblastoma.
Keywords
Neuroblastoma , Neurotrophins , expression profiling , Trk receptors , Microarrays
Journal title
Cancer Letters
Serial Year
2005
Journal title
Cancer Letters
Record number
1817495
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