Title of article :
A novel translocation involving chromosomes 2, 9, 14, and 22 in chronic myeloid leukemia
Author/Authors :
Endo، نويسنده , , Kazuyasu and Sato، نويسنده , , Akiyoshi and Sugawara، نويسنده , , Tomohiro and Kameoka، نويسنده , , Junichi and Fukuhara، نويسنده , , Osamu and Meguro، نويسنده , , Kuniaki and Shishido، نويسنده , , Tomoaki and Abe، نويسنده , , Keishi، نويسنده ,
Abstract :
A 46-year-old man with chronic myelogenous leukemia was found to have a new complex translocation. In chronic phase, all of the bone marrow cells had a rearrangement of a t(2;9;14;22) (p21;q34;q32;q11). Southern blot analysis of leukocyte DNA revealed rearrangement of the breakpoint cluster region (bcr) within the 5.8-Kb bcr. The patient eventually died in blast crisis 28 months later. The cytogenetic findings of bone marrow cells showed a 46,XY,t(2;9;14;22)(p21;q34;q32;qll),add(lp),del(3q) karyotype in blast crisis.
